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[16] The catalysis is performed by one enzyme and the only precursor step, if there is one, is generally cleavage to activate it from a zymogen

This is because E2 production by the follicles in the ovaries is inhibited due to the inhibitory effect of the COC on follicle stimulating hormone (FSH) production, which normally results in follicular maturation

The powder format also makes it convenient for those who prefer mixing supplements into water rather than taking capsules

Possible heterogeneity may also mean that one single biological measure may not be feasible as a marker for ME/CFS

Schopfer FJ, Cipollina C, Freeman BA