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These data were later confirmed in a study in vivo on a pig model

[91] [92] Fatty acids, serving as an energy source for photoreceptor cells, and their oxidative metabolites also influence eye diseases

In this respect, an interesting study conducted on immortalized human microglia cells (CVCL_5G94) highlighted how ATRAs can increase the heat shock protein 90 (Hsp90) expression on the surface of these cells, causing an increase in the amount of endocytosed and consequently eliminated tau protein (25)