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doi: 10.1016/j.amjcard.2013.09.021 3 AokiK.UchiharaT.SanjoN.NakamuraA.IkedaK.TsuchiyaK.et al

Endoplasmic Reticulum stress leads to protein misfolding and activation of the unfolded protein response (UPR), which promotes ROS generation, influencing cell survival and drug resistance [73]