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Integrating multi-omics data, a pathway analysis, and computational modeling may offer powerful tools to investigate metabolic reprogramming in ECs during aging and atherosclerosis, as exemplified by Kalucka et al.s single-cell RNA-sequencing (scRNA-Seq) atlas of 11 mouse tissues, which revealed 78 EC subclusters and highlighted tissue origin as the primary determinant of EC heterogeneity, including tissue-specific metabolic profiles [234]

doi: 10.1136/jitc-2020-001369 41 Del PreteASalviVSorianiALaffranchiMSozioFBosisioDet al

Effects of ascorbic acid on glucose-6-phosphate dehydrogenase-deficient erythrocytes: studies in an animal model

In almost every case where glutathione was linked to a severe cardiovascular event, the situation involved: High-dose IV therapy rather than oral supplements

While there have been conflicting reports regarding ROS generation in cells treated with NSAIDs 53 , colon cancer cells reportedly exhibit stronger ROS generation than other cancer cell types 54,55 , which is consistent with the findings of our present study