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Pressure (means SD, cm H2O) in lower esophageal sphincter and pyloric sphincter throughout the days after duodenocutaneous fistula formation in controls saline 5 ml/kg intraperitoneally once daily, drinking water only (12 ml/day/rat), BPC 157 10 g/kg or 10 ng/kg, given intraperitoneally, once daily or perorally, in drinking water (0.16 g/ml or 0.16 ng/ml), L-NAME 5mg/kg intraperitoneally, once daily, L-arginine 100 mg/kg intraperitoneally, once daily, (given alone or together), treated rats

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The study also identified a specific chain of events, or signaling pathway, that BPC-157 activates to produce nitric oxide