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In spinal cord tissues from patients with ALS, the expression of arachidonate 5-Lipoxygenase (ALOX5) and complement component 3 (C3) was markedly upregulated, accompanied by reduced GSH levels, elevated iron concentrations, and enhanced lipid peroxidation

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Introduction The liver is a major site of metabolism and detoxification of drugs and xenobiotics in the human body ( CYP2E1 ) increases, with an increase in the formation of a highly reactive toxic intermediate metabolite, N-acetyl-p-benzoquinone imine (NAPQI) (Wang et al., 2017)

2013;73(15):1681-9 Zhang XH, Wang L, Dong ZZ

These advances allow researchers not only to examine the entire TME but also to investigate specific cell subtypes within it