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As a result, diclofenac inhibits cyclooxygenase isoforms now known as (COH1 and COH2)

This cumulative effect on digestion may make gastrointestinal side effects feel more pronounced than they would from either substance alone

Boisen KA, Kaleva M, Main KM, Virtanen HE, Haavisto A, Schmidt IM, Chellakooty M, Damgaard IN, Mau C, Reunanen M, Skakkebaek NE, Toppari J (2004) Difference in prevalence of congenital cryptorchidism in infants between two Nordic countries

And for men, that starts with giving progesterone the respect it deserves