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On the other hand, iron is a prooxidant and can increase OS in the brain by participating in Fentons reaction and contributing to the formation of reactive oxygen species (ROS)

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Presupplementary motor area hyperactivity during response inhibition: a candidate endophenotype of obsessive-compulsive disorder

In turn, enhancing KCC2 activity not only potentiated L838,417-induced analgesia, it rescued its analgesic potential at high doses, revealing a novel strategy for analgesia in pathological pain, by combined targeting of the appropriate GABA A R-subtypes and restoring Cl - homeostasis