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Because the two peptides hit two separate receptors that both feed the same GH pulse, they are described in research as synergistic rather than additive: GHRH-driven and secretagogue-driven signals combine at the pituitary

Ipamorelin 7 causes a sharp GH peak roughly 0.67 hours after dosing, then declines over the next few hours due to its short half-life (~2 hours)

International Journal of Obesity Related Metabolic Disorders 25(5): 63-67

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Neuromuscular function was determined via balance beam in females [Young ( n = 8), Old Con ( n = 12), and Old mAb ( n = 15)] and males [Young ( n = 8), Old Con ( n = 9), and Old mAb ( n = 9)]