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Sleep paralysis, hypnagogic hallucinations, and cataplexy, among other REM sleep-related abnormalities, are likely caused by a particular combination of pathophysiologic conditions in the brain (Mitler et al., 1987)

Yang et al., 2018), both directly through activation of the HIF-1 promotor region, and indirectly by downregulation of HIF degradation by prolyl hydroxylases or activation of lipid rafts (Frede et al., 2006

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Conversely, drugs with high bioavailability have a marginally clinically relevant increase in systemic drug concentration

The latter increases with increasing purulence owing to the presence of cellular debris