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DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance

doi: 10.1183/09031936.03.00039602

plantarum STIII (5 108 CFU/g, 0.8 ml/d) by intragastric tube feeding for two consecutive weeks exhibited improved social impairment, self-effacement, and freezing time

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239 Notably, treatment with a methionine-/cystine-restricted diet significantly increased the number of tumor-infiltrating CD8 + T cells and cytotoxic granzyme B + CD8 + T cells, which was further enhanced when combined with immunotherapy