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It was observed that pro-inflammatory cytokines enhance CHI3L1 expression in adipocytes, suggesting a strong association between CHI3L1 and obesity, as well as obesity-induced pro-inflammatory responses ( The observation of a bioactive lipid, sphingosine-1-phosphate (S1P), demonstrated potent regulation of the expression of several genes involved in the control of cell proliferation and airway remodeling ( HBEGF, TGFB3, TXNIP, PLAUR, SERPINE1, RGS4 ) ( The association between genetic predisposition and obesity-related airway remodeling intricately involves the role of adipokines

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Mice expressing adipocyte NDI1 displayed similar weight gain, activity, caloric intake, energy expenditure, fat pad weights and body composition during HFD feeding compared with control mice (Fig

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Known Adverse Reactions: Mild gastrointestinal symptoms (transient nausea, vomiting, abdominal cramps, diarrhea) have been reported