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Excessive alcohol consumption depletes glutathione stores

By interacting with the Lys140 residue of NIMA-related kinase 7 (NEK7), A20 and its derivative peptides hinder the NEK7-NLRP3 interaction, suppress macrophage STING signaling and NLRP3-mediated pyroptosis, and thereby effectively relieve auto-DNA-induced AKI [179]

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Besides substrate availability, GCL is the rate-limiting enzyme in GSH synthesis, which presents two different subunits: the catalytic subunit (GCLC), containing the active site responsible for the bond formation between the amino group of cysteine and the -carboxyl group of glutamic acid, and the modifier subunit (GCLM) that interacts with GCLC, increasing the catalytic efficiency of GCLC [5]

Firstly, we advocate for the development of drugs aimed at optimizing mitochondrial energy metabolism