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Statements Author contributions YX and MW designed the manuscript

Previous medications offered modest 5-10% weight loss at best

Read article Skin Care Chemical Peel for Hyperpigmentation and Melasma How chemical peels help treat hyperpigmentation and melasma, what to expect, and physician-led care at True Bliss Medical in Verona, New Jersey

Ipamorelin Dosing Schedule (Community-Derived) Phase Assessment Timing Week 1 Daily Dose 100 mcg/day Frequency 1x at bedtime, fasted Phase Titration Timing Weeks 2-3 Daily Dose 200 mcg/day Frequency 1x bedtime, or split 100 mcg AM + 100 mcg PM Phase Standard Timing Weeks 4-8 Daily Dose 200-300 mcg/day Frequency 1-2x daily (AM fasted + bedtime is common) Phase Extended Timing Weeks 9-12 Daily Dose 200-300 mcg/day Frequency Continue if tolerated

KPV (Lysine-Proline-Valine) is a tripeptide corresponding to amino acids in the C-terminal sequence of alpha-melanocyte stimulating hormone (-MSH)