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Dysbiosis and increased intestinal permeability (leaky gut) may amplify neuroinflammatory state of the brain, further justifying the need for research into interventions combining metabolic and microbiota-based therapies

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The regulation of the inflammatory response by macrophages and the regulation of the balance between M1 and M2 macrophages would be a benefit for the understanding of the mechanisms of the immunosuppressives phenotype in the tumor

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