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Indeed, many examples have been described in which the inclusion of complement increases nAb potency in vitro 107,108,109,110 , and for WNV this was shown to be mechanistically associated with reducing the stoichiometry of antibody-mediated neutralization 107

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178,179,180,181,182 Given that DNA damage-activated PARPs account for up to 90% of cellular NAD + consumption, the DNA repair activity is highly dependent on the cellular NAD + concentration