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Altered S -nitrosothiol homeostasis provides a survival advantage to breast cancer cells in HER2 tumors and reduces their sensitivity to trastuzumab

SLC39A1 lko mice displayed reduced tumor number in DEN-CCL4 model compared with SLC39A1 flox/flox mice, evidenced by reduced liver damage, hepatocyte proliferation (Ki-67), inflammation (TGF-), and fibrosis (Masson), accompanied by increased ROS accumulation and decreased LC3 and Lamp1

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