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Following ferroptosis activation, the cell membrane ruptures and HMGB1::Lucia is released in the extracellular milieu

It classically presents in children under five years old as a large, palpable, unilateral flank mass, often accompanied by hematuria and hypertension

Therefore, the longevity of PD is limited and most PD patients eventually switch to Haemodialysis (HD) within a few years

However, this effect was not reproduced in vivo: in the ileum and colon of metformin-treated mice, GLUT1 expression was markedly increased, whereas ATF4 levels remained unchanged (Supplementary Fig

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