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In parallel, supercharged NK cells generated through combined cytokine and co-stimulatory receptor signaling have shown strong melanoma control in humanized mice, suggesting an additional route to enhance NK potency with or without CARs [244, 245]

If the patient opts for the SC formulation as maintenance treatment, it must be initiated following at least two IV infusions (at weeks 0 and 2)[86]

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These limitations dont invalidate the positive safety findings but do suggest that comprehensive medical supervision remains appropriate for anyone using AOD-9604, particularly for off-label applications or extended treatment periods

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