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IGF1 and IGF2 have been shown to bind to hybrid receptors with high affinity whereas human insulin binds with low affinity 9,10

for this reason, physicians typically advise patients to dose in a fasted state, whether at bedtime or earlier in the day

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Nutrients , 15 (17), 3693

Despite there being various techniques to encapsulate the drugs and increase encapsulation efficiency, the freeze-thaw cycling and reverse phase evaporation techniques are used extensively [135]