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The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations

In parallel, the palmitoylation of cGAS at Cys 404/405 promotes its functional activation through two distinct mechanisms: (1) augmenting cytoplasmic double-stranded DNA (dsDNA) sensing capacity, and (2) facilitating cGAS dimerizationa prerequisite conformational change for enzymatic activation