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Long-term histological response to intravenous Teflon and silicone in a rat model

Dosing frequency appears to correlate strongly with study objectives

In both the P4S-bound or apo inward-open structure, a pronounced bend of TM1a towards the membrane plane, coupled with unwinding of the intracellular side of TM5, collectively open a solvent-accessible pathway to the cytoplasm (Fig