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In addition, GSTs may participate in the passive non-catalytic binding of substrates and sequestration, which prevents the binding of xenobiotics to their target proteins [45-48]

Hyperinsulinemia resulting from insulin resistance stimulates excessive androgen production by the ovaries and adrenal glands, exacerbating hyperandrogenemia and ovulatory dysfunction ( e.g ., diet and exercise) and pharmacological treatments ( e.g ., metformin, GLP-1 receptor agonists) can ameliorate insulin resistance and improve metabolic outcomes in PCOS ( 2.3 Hormonal imbalance Hyperandrogenemia is a defining feature of PCOS, characterized by elevated serum testosterone, androstenedione, and dehydroepiandrosterone (DHEA) levels, leading to clinical manifestations such as hirsutism, acne, and alopecia

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After exposure to ultrasound from clinical phacoemulsification, the areas of damaged corneal endothelium in rabbits become re-covered with endothelial cells within 24 h of exposure, and corneal thickness returns to control levels in the same timeframe 51

TNBC, the most malignant subtype of breast cancer, was previously reported to be intrinsically sensitive to ferroptosis due to its non-apoptotic characteristics