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Targeting CD38 in vivo blocks mitochondrial transfer and improves animal survival in mice, demonstrating a consistently reduced tumor burden in bone marrows [26]

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Blood 131:1329 Deaglio S, Morra M, Mallone R, Ausiello CM, Prager E, Garbarino G et al (1998) Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member

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For most researchers, the dual AOD 9604 plus tirzepatide combination provides sufficient metabolic coverage without the risks of more complex stacks