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These M1-like macrophages express a high level of CD38 and enhance the CD38 dependent NADase activity, thus reducing the tissue NAD level, while the decrease in NAD + levels related to aging might weaken SASP and reduce its pathological effect ( The Relationship Between the Expression Level of CD38 on the Macrophage Surface and Disease Diagnosis, Treatment, and Prognosis The increase of macrophage CD38 is observed in many diseases, for example, the expression of renal macrophage CD38 in lupus nephritis is significantly increased ( In the tumor microenvironment, CD38 + macrophages contribute to the anti-tumor effect