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A systemic review found that NRT was relatively safe to be used in most patients for the short-term, but skin reaction, gastrointestinal upset, and palpitation were common 20

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This rate increases significantly in patients who smoke

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Among the patterns they have begun to trace are that the majority of patients are young men, with a median age of 19, who are described as generally healthy. Typically they report respiratory problems, fever, and other symptoms, and all reported using a vape product within the last 90 daysnearly all vaped within the last seven dayswith a majority of those afflicted using both what they believed to be nicotine and THC products within that time period