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While preparing this manuscript for submission, a study based exclusively in in vitro assays was published showing that the addition of 25 M BSO or the use of tools to delete GCLC inhibits the growth of Burkitt lymphoma cell lines under 2D culture conditions [42], seemingly suggesting a comparable susceptibility to glutathione starvation between TICs and differentiated tumor cells

NAD + /NADH ratios reflect redox status and play an integral part in the ETC, with NADH being the primary electron donor

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Choi S Y, Ko E J, Lee Y H, et al