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Since the discovery of FSP1, more and more GPX4-independent ferroptosis pathways have been discovered in various physiological and pathological processes Drugs targeting GPX4-independent ferroptosis pathway may become a new direction for the treatment of diseases

Rimland B

10.1055/a-2003-9406 151

Mitochondrial carriers (MCs) are a group of transport proteins located in the mitochondrial membrane and primarily responsible for mediating the translocation of metabolites between mitochondria and the cytoplasm, which is indispensable for modulating metabolic activities and maintaining homeostatic balance [9, 10]

Glutathione does not contribute to any of these pathways