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HA-344 and #231 as dual inhibitors of GPX4 and TXNRD1 in AML cells In the same line, we recently designed two covalent small molecule inhibitors, that can concomitantly inhibit GPX4 and TXDNR1, two critical proteins involved in the protection of cell from ferroptosis and apoptosis [39]

The mechanisms of glutamine addiction in different types of cancer cells differ, and these differences are caused by the different metabolic pathways of different tumor cells and the influence of the tumor microenvironment