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Conversely, it has been shown that antihypertensive treatment reduces oxidative stress and results in increased GSH, decreased GSSG, and significant enhancement of enzymes involved in glutathione metabolism (19)

It improves the therapeutic efficacy of TMZ against glioblastoma by reducing autophagy through suppression of ERK activation using an antioxidant mechanism and subsequently augmenting apoptosis observed in both in vitro and in vivo [141]