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This NADPH stress suppresses the rate of lipogenesis and increases sensitivity to oxidative stress in mtIDH1 cells in culture 156 , despite mtIDH1 cells exhibiting increased oxPPP flux 157

Ferroptosis, a distinct form of cell death driven by oxidative stress, has been implicated in the pathogenesis of various central nervous system disorders, including Parkinsons disease (Zhao et al., 2020), Alzheimers disease (Lane et al., 2021), Huntingtons disease (Skouta et al., 2014), epilepsy (Cai and Yang, 2021), and traumatic brain injury (Rui et al., 2021)

The goals of therapy are to control inflammation, correct nutritional deficiencies, and relieve symptoms such as abdominal pain, diarrhea, and rectal bleeding

Vyssoki B, Praschak-Rieder N, Sonneck G, et al

Zhang J, Hu L, Wang H, Zhi J, Hou X, Wu Y, et al