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International Journal of Molecular Sciences, 14 (4), 8638-8683

L.EngelstoftM

Since the level of ERG produced depends strictly on the availability of three distinct precursor amino acids (l-cysteine (Cys), l-histidine, and l-methionine (Met)), metabolic engineering for enhancement of the flux toward ERG biosynthesis is required

10 Glutathione-triggered sensing and imaging strategies Glutathione (GSH) is highly abundant in tumors and serves as a valuable target for redox-responsive diagnostics

Cys, predominantly in its oxidized dimeric form (Cys), plays a critical role in preserving and restoring the structural integrity of TJs between IECs, which are vital for regulating intestinal barrier permeability