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Surprisingly, direct pulmonary treatment with surfactant, liquivent, N-acetylcysteine, dexamethasone, or anti-sense syk oligonucleotides 2 min post-exposure did not significantly increase the survival rate of VX-exposed guinea pigs

Sussan TE, Rangasamy T, Blake DJ, Malhotra D, El-Haddad H, Bedja D, Yates MS, Kombairaju P, Yamamoto M, Liby KT, Sporn MB, Gabrielson KL, Champion HC, Tuder RM, Kensler TW, Biswal S (2009) Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

Mol Cell 11: 619633 Haynes CM, Titus EA, Cooper AA (2004) Degradation of misfolded proteins prevents ERderived oxidative stress and cell death

Fetal bovine serum (FBS, Cat# 10270106), Dulbeccos modified eagles medium (DMEM, Cat# 12100046) with high glucose, antibiotic and antimycotic solution (Cat#15240062), and trypsinEDTA solution (Cat# 25200072) were purchased from Gibco, Thermo Fisher Scientific Inc, USA

Citation21 Inhibition of SLC7A5 reduced mTORC1 activities in T cells from older individuals, which restored TFH generation in aged T cells