Ultimately, personalized nutritional strategies-incorporating genetic background, trace element status, and gut microbiota composition-represent a promising direction for the precise prevention and management of AITD ( Figure 1 )
declares speaker honoraria from AstraZeneca, Roche and Boston Scientific and advisory honoraria from AstraZeneca, Incyte, Boston Scientific and Taiho
When they tested her other nutrients, they found she was severely deficient in both magnesium and zinc
Abbreviations BSA: Bovine serum albumin COPD: Chronic obstructive pulmonary disease CRD: Chronic respiratory disease CS: Cigarette smoke HCl: Hydrochloric acid HDM: House dust mite HNE: Human neutrophil elastase ICS: Inhaled corticosteroid ILDs: Interstitial lung diseases LPS: Lipopolysaccharide NF-B: Nuclear factor kappa B NLRP3: NOD-like receptor family pyrin domain containing 3 Nrf-2: Nuclear factor erythroid 2related factor 2 Keap-1: Kelch-like ECH-associated protein 1 OVA: Ovalbumin PM/PMs: Particulate matter PTEN: Phosphatase and tensin homolog TGF-: Transforming growth factor beta References Adcock IM, Mumby S (2016) Glucocorticoids
Additionally, we examined the coding sequences (CDS) and non-coding regions (UTRs) of the AsGST gene family (Fig