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However, FRDA iPSC-based cells had functional mitochondria and functional secretion of glucose-induced insulin ( Therapeutic solutions for Friedreichs ataxia with the help of induced pluripotent stem cell-based technologies Heterochromatin formation around the FXN gene is the major reason for the downregulation of the FXN gene in FRDA ( FXN gene ( in vitro models ( FXN levels along with a decrease in oxidative stress response ( FXN reporter system revealed HDAC inhibitors as the only compounds that could upregulate FXN levels ( Recent advances in genome editing enabled the correction of expanded alleles in FRDA

These data suggested that GSH has very important functions in morphogenesis by promoting the formation of stable capsid precursors and of the mature virus