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Likewise, miR-19a-3p has been implicated in neuroinflammation through its interaction with tumor necrosis factor-alpha (TNF- ) (225, 232)

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Elevated ESR and CRP indicate systemic inflammation, while positive rheumatoid factor and high antiCCP levels demonstrate serologic evidence of autoimmune activity

This life-threatening complication, though inherent to AOSD pathophysiology, may be precipitated by therapeutic immune modulation (Junge et al., 2017)

A previous network meta-analysis for acne vulgaris published by Shi et al found that pharmacological interventions are generally more effective than non-pharmacological interventions