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Critical unresolved issues include identifying the molecular switches that govern the transition of autophagy from an anti- to a pro-ferroptotic state, elucidating subtype-specific differences in crosstalk mechanisms, and clarifying the molecular basis underlying proteins such as COX7A1 to exhibit opposing functions

Results: A total of 84 patients that were ever treated with givosiran were enrolled (acute intermittent porphyria, N=75

It facilitates glymphatic clearance, a convective exchange of CSF and interstitial fluid (ISF) that removes metabolic waste, but also A and tau [359, 366]

doi: 10.1186/s12953-019-0155-y

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