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Description

23 Daniel Bovet synthesized antihistamines in 1937 and earned the Nobel Prize in Physiology or Medicine in 1957, which brought hope in the treatment of allergic diseases and has been in clinical use to this day

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To maintain redox homeostasis, neurons rely on antioxidant systems such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) to neutralize free radicals

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The evidence that hypotaurine, through its binding to soluble A, reduces the production and aggregation of oligomers, as well as its ability to lessen the toxicity of -amyloid (A) in primary cultured neurons and amyloid plaques in a mouse model, provides support for this assertion (129)

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Changes in circulating histamine were examined by mass spectrometry

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Activating Transcription Factor 3 (ATF3), a member of the ATF/Cyclic AMP Response Element-Binding protein (CREB) transcription factor family, plays a crucial role in transcriptional repression and promotion with a dual function of regulating cell apoptosis, proliferation, and the cell cycle

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