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In contrast, people lacking functional CD73 are more prone to organ damage during hypoxic stress, particularly in the heart, brain, and kidneys (Ndzie Noah et al., 2024)

Distinguished by its unique ability to inhibit the ectoenzymatic activity of CD38, Isatuximab diverges from Daratumumab by binding to a distinct epitope on CD38, which encompasses the CD38 ectoenzyme catalytic site

Optogenetic inhibition reversed allodynia and pricking and cold hyperalgesia, as well as joint pain behavior, limb dysfunction and paw dexterity deficits during and after inflammation (Fig