In a clinical trial of 71 women with mild to advanced photoaging, a GHK-Cu facial cream applied daily for twelve weeks significantly increased skin density and thickness while reducing fine lines, wrinkles, and laxity
The tradeoff is doubling the number of injection events per week
Deficiencies in many of the B vitamins results in negative cognitive effects (see Consequences of Select Micronutrient Deficiencies), and a number of studies have linked lower blood levels of B vitamins with some cognitive impairments (147-154)

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It is primarily used to fortify cereal-based products