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(3) Medication availability: Essential medications aligned with national guidelines should be available, including agents for cardiometabolic risk management and hepatoprotective medications where indicated

Oral administration is possible in preclinical research

Arch Intern Med 151:11891191 Riordan SM, Williams R (2002) Alcohol exposure and paracetamol-induced hepatotoxicity

These mechanisms alter chromatin structure, modulating gene expression related to neuronal plasticity and responses to stress, depression, and antidepressants 9,129

The data were analyzed by one way ANOVA and by repeated measures ANOVA, followed by Dunnett's test for multiple group comparisons, using SPSS software (SAS Institute Inc., Cary, NC)