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Supplementary material The Supplementary Material for this article can be found online at: Glossary 2-HB 2-hydroxybutyric acid AA arachidonic acid AUC area under the curve COPD chronic obstructive pulmonary disease COX cyclooxygenase CYP450 cytochrome P450 dhS1P dihydrosphingosine-1-phosphate/sphinganine-1-phosphate dhSph dihydrosphingosine DM Dermatomyositis DM-ILD DM-associated with ILD DM-nonILD DM without ILD FC fold change FDR false discovery rate GPR55 G protein-coupled receptor 55 HCs healthy controls H-DM high disease activity DM HODEs hydroxy-octadecene dienoic acid ILA Indole-3-lactic acid ILD interstitial lung disease LA linoleic acid L-DM low disease activity DM LOX lipoxygenase LPA lysophosphatidic acid LPC lysophosphatidylcholine LPE lysophosphatidylethanolamine LPI lysophosphatidylinositol MSAs myositis-specific autoantibodies MYOACT Myositis Disease Activity Assessment Visual Analogue Scales OPLS-DA orthogonal partial least square discriminant analysis PC phosphatidylcholine PCA principal component analysis PLS-DA partial least squares discrimination analysis QC quality control RF random forest ROC Receiver operating characteristic ROS reactive oxygen species S1P sphingosine-1-phosphate S1PR1 G-protein-coupled S1P receptor SVM support vector machines UPLC-TOF-MS ultra-high performance liquid chromatography-composed time-of-flight mass spectrometry VIP variable importance in the projection References 1 DeWaneMEWaldmanRLuJ