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Often there are associations and correlations found but its rare and extremely exciting to find something that actual a direct effect

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Indeed, we could assemble octasomes with both (H3/H4) 2 and (CENP-A/H4) 2 tetramers on 601 positioning and on natural centromeric alpha-satellite DNA, albeit 2x(CENP-A/H4) 2 octasomes consistently assemble with lower efficiency (Fig S1B)

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Gerardi DG, Tinucci-Costa M, Silveira ACT, Moro JV

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Following synthesis, the crude peptide undergoes purification using reverse-phase high-performance liquid chromatography (RP-HPLC) to remove synthesis-related impurities and isolate the target compound

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