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[16] The catalysis is performed by one enzyme and the only precursor step, if there is one, is generally cleavage to activate it from a zymogen

Wu W, Peden DB, McConnell R, Fruin S, Diaz-Sanchez D

The results from the Boston collaborators raised questions about the physiological way that GLP-1 prompted the release of insulin, a phenomenon described as an 'insulinotropic effect' (Drucker, Philippe, Mojsov)