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alternatively activated (M2) macrophages, by contrast, express molecules such as Arg1, CD206, and IL-10 in response to interleukin-4 (IL-4), interleukin-13 (IL-13), or IL-10 stimulation, and participate in inflammation resolution and tissue repair ( in vivo do not exist as fixed binary states, but rather more closely resemble a continuum of functions jointly shaped by tissue niches, inflammatory stages, and substrate availability, with their phenotypes being collectively determined by microenvironmental signals, metabolic reprogramming, and epigenetic regulation ( Figure 2 , classically activated M1 macrophages and alternatively activated M2 macrophages differ markedly in inducing signals, secreted factors, and functional characteristics, while M2 macrophages can be further subdivided into multiple subtypes (M2a, M2b, M2c, and M2d)

Shen J, Kim HC, Su H, Wang F, Wolfram J, Kirui D, et al

5,135.9 g/mol Purity 98% CAS No

Clinical remission (measured by Simple Clinical Colitis Activity Index- SCCAI 2) was achieved by 53.8% of the curcumin group compared to none in the placebo group, and clinical response (3 point reduction in SCCAI) occurred in 65.3% of the curcumin group versus 12.5% in the placebo group