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Furthermore, when ROS exceeds a certain threshold, it leads to oxidative stress ( Mechanisms governing ferroptosis Ferroptosis, unlike apoptosis, autophagy, and cell necrosis, is a regulatory form of cell death that depends on iron and ROS

doi: 10.1186/s40880-018-0288-x 106 KoppulaP.ZhuangL.GanB

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As an important substrate for lactylation, the increase in lactate concentration significantly enhances the level of lactylation and has a crucial impact on the final outcome of IRI