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During development and progression of atherosclerosis, Nrf2 signaling modulates many physiological and pathophysiological processes, like regulation of lipid homeostasis, CD36 gene expression regulation, foam cell formation, macrophage polarization, immunity regulation (Th2 differentiation and inhibition of pro-inflammatory gene expression through NFB down-regulation), redox regulation and inflammation, improvement of endothelial dysfunction, as well as GSH synthesis and utilization (234245)

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478,479 One application for the diversity of ncAAs compatible with PURE-based systems is peptide drug discovery

Beyond its anti-inflammatory and antioxidant properties, EGCG modulates key signaling pathways that regulate neuronal survival