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For instance, treatment with SGLT2 inhibitors results in a decline in long-chain acylcarnitines that parallels improvements in mitochondrial function and correlates with a slower rate of eGFR decline [168], suggesting that these metabolites can serve as sensitive pharmacodynamic biomarkers

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These inhaled insulin programmes, although eventually discontinued following the market challenges of Exubera 246 laid important groundwork for engineering inhalable biologics and other therapeutics aimed at systemic administration with a need for accurate control over systemic exposure

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