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Impaired glymphatic function and clearance of tau in an Alzheimers disease model

Lacey Johnson is a writer and editor whose has contributed to Cosmopolitan, Marie Claire, Womans Day, POPSUGAR and others, and is the founder of The Wonder Report

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FIGURE 4 APC (adenomatous polyposis coli) encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway

For instance, recent studies have proposed a CRISPR-Cas9 based tool containing a deactivated Cas9 (dCas9) nuclease fused with a catalytic domain of DNMT and combined with co-expressed sgRNA, which achieves precise DNA methylation for specific targeted regions that are heritable across mitotic divisions in daughter cells [332, 333]