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Wang, C., Esteve-Zarzoso, B., & Mas, A

Although MSCs can be isolated from diverse tissuessuch as adipose tissue, bone marrow, umbilical cord, and dental pulptheir yield and proliferative capacity vary by source, and extensive in vitro expansion may alter their phenotype and potency [56,57,58]

The effect, however, may be specific to this particular mammalian enzyme

Peroxisome proliferator gamma coactivator (PGC), in association with PPAR activation, leads to a variety of cellular protective responses including mitochondrial biogenesis [57]

Different studies have reported a wide variation in the prevalence of vitamin B12 deficiency in metformin users, with incidence ranging from 6% to 50%